SEPAGES is a couple-child cohort aiming at describing the exposure of pregnant women and children to environmental contaminants and to characterize and better understand the possible effect of these contaminants on the health of pregnant women, foetuses and children.

The cohort is being set up in Grenoble area and is coordinated by Inserm (the French Institute of Health and Medical Research) and Grenoble University, with the support of Grenoble University Hospital and of the 4 maternity clinics of Grenoble urban area.

The cohort is primarily focused on the impact of atmospheric pollution and of non-persistent chemical compounds able to act as endocrine disruptors, such as the compounds of the phenols family (including bisphenol A and its substitutes, parabens, triclosan and benzophenone) on the health of pregnant women and their offspring.

About 700 families (mother, father and child) will be followed-up, since the first half of pregnancy, and followed-up several years.

A specific effort is done in terms of quality of the information collected regarding environmental exposures during pregnancy and after birth. Advanced individual tools (GPS, accelerometers, personal air pollution monitors…) are being used and a very rich biobank is being collected, including repeated urine samples, parental blood, cord blood, and postnatal samples.

Scientific communications
Marion Ouidir, ISEE, Seattle, August 2014:
Title: Taking into Account Space-Time Activity and Indoor Air Levels in the Estimation of Exposure to Atmospheric Pollutants during Pregnancy: Does It Make a Difference?
Autjors: Marion Ouidir, Lise Giorgis-Allemand, Sarah Lyon-Caen, Xavier Morelli, Johanna Lepeule, Valérie Siroux, Rémy Slama